翻訳と辞書 Words near each other ・ Discovery and development of antiandrogens ・ Discovery and development of beta-blockers ・ Discovery and development of beta2 agonists ・ Discovery and development of cephalosporins ・ Discovery and development of cyclooxygenase 2 inhibitors ・ Discovery and development of direct thrombin inhibitors ・ Discovery and development of gliflozins ・ Discovery and development of HIV-protease inhibitors ・ Discovery and development of integrase inhibitors ・ Discovery and development of matrix metalloproteinase inhibitors ・ Discovery and development of memantine and related compounds ・ Discovery and development of neuraminidase inhibitors ・ Discovery and development of non-nucleoside reverse-transcriptase inhibitors ・ Discovery and development of nucleoside and nucleotide reverse-transcriptase inhibitors ・ Discovery and development of phosphodiesterase 5 inhibitors ・ Discovery and development of proton pump inhibitors ・ Discovery and development of statins ・ Discovery and development of steroidal aromatase inhibitors ・ Discovery and development of triptans ・ Discovery and development of TRPV1 antagonists ・ Discovery and development of tubulin inhibitors ・ Discovery and exploration of the Solar System ・ Discovery and Launch ・ Discovery Arcade (Disneyland Paris) ・ Discovery Atlas ・ Discovery Aviation Model 201 ・ Discovery Bay ・ Discovery Bay (Antarctica) ・ Discovery Bay (Australia) ・ Discovery Bay (disambiguation) Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Discovery and development of proton pump inhibitors ： ウィキペディア英語版 Discovery and development of proton pump inhibitors Proton pump inhibitors (PPIs) block the gastric hydrogen potassium ATPase (H+,K+-ATPase) and inhibit gastric acid secretion. These drugs have emerged as the treatment of choice for acid-related diseases, including gastroesophageal reflux disease (GERD) and peptic ulcer disease. PPIs also can bind to other types of proton pumps such as those that occur in cancer cells and are finding applications in the reduction of cancer cell acid efflux and reduction of chemotherapy drug resistance. ==History== Evidence emerged by the end of the 1970s that the newly discovered proton pump (H+,K+-ATPase) in the secretory membrane of the parietal cell was the final step in acid secretion. Literature from anaesthetic screenings led attention to the potential antiviral compound pyridylthioacetamide which after further examination pointed the focus on an anti-secretory compound with unknown mechanisms of action called timoprazole. Timoprazole is a pyridylmethylsulfinyl benzimidazole and appealed due to its simple chemical structure and its surprisingly high level of anti-secretory activity. Optimization of substituted benzimidazoles and their antisecretory effects were studied on the newly discovered proton pump to obtain higher pKa values of the pyridine, thereby facilitating accumulation within the parietal cell and increasing the rate of acid-mediated conversion to the active mediate. As a result of such optimization the first proton pump inhibiting drug was released on the market, omeprazole. Other PPIs like lansoprazole and pantoprazole would follow in its footsteps, claiming their share of a flourishing market, after their own course of development. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Discovery and development of proton pump inhibitors」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.